The C. elegans sex determination protein MOG-3 functions in meiosis and binds to the CSL co-repressor CIR-1
- Kasturi, Prasad Department of Biology, University of Fribourg, Switzerland
- Zanetti, Simone Department of Biology, University of Fribourg, Switzerland
- Passannante, Myriam Department of Biology, University of Fribourg, Switzerland
- Saudan, Zarifja Department of Biology, University of Fribourg, Switzerland
- Müller, Fritz Department of Biology, University of Fribourg, Switzerland
- Puoti, Alessandro Department of Biology, University of Fribourg, Switzerland
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15.05.2010
Published in:
- Developmental Biology. - 2010, vol. 344, no. 2, p. 593-602
English
In the germ line of the Caenorhabditis elegans hermaphrodite, nuclei either proliferate through mitosis or initiate meiosis, finally differentiating as spermatids or oocytes. The production of oocytes requires repression of the fem-3 mRNA by cytoplasmic FBF and nuclear MOG proteins. Here we report the identification of the sex determining gene mog-3 and show that in addition to its role in gamete sex determination, it is necessary for meiosis by acting downstream of GLP-1/Notch. Furthermore, we found that MOG-3 binds both to the nuclear proteins MEP-1 and CIR-1. MEP-1 is necessary for oocyte production and somatic differentiation, while the mammalian CIR-1 homolog counters Notch signaling. We propose that MOG-3, MEP-1 and CIR-1 associate in a nuclear complex which regulates different aspects of germ cell development. While FBF triggers the sperm/oocyte switch by directly repressing the fem-3 mRNA in the cytoplasm, the MOG proteins play a more indirect role in the nucleus, perhaps by acting as epigenetic regulators or by controlling precise splicing events.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 20321
- DOI 10.1016/j.ydbio.2010.05.009
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301676
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