Journal article

JNK1 and IKKβ: molecular links between obesity and metabolic dysfunction

  • Solinas, Giovanni Laboratory of Metabolic Stress Biology, Department of Medicine, Physiology, University of Fribourg, Switzerland
  • Karin, Michael Laboratory of Gene Regulation and Signal Transduction, Department of Pharmacology, School of Medicine, University of California–San Diego, USA
    06.04.2010
Published in:
  • The FASEB Journal. - 2010
English Inflammation is thought to underlie the pathogenesis of many chronic diseases. It is now established that obesity results in a state of chronic low-grade inflammation thought to contribute to several metabolic disorders, including insulin resistance and pancreatic islet dysfunction. The protein kinases JNK1 and IKKβ have been found to serve as critical molecular links between obesity, metabolic inflammation, and disorders of glucose homeostasis. The precise mechanisms of these linkages are still being investigated. However, as we discuss here, JNK1 and IKKβ are activated by almost all forms of metabolic stress that have been implicated in insulin resistance or islet dysfunction. Furthermore, both JNK1 and IKKβ are critically involved in the promotion of diet-induced obesity, metabolic inflammation, insulin resistance, and β-cell dysfunction. Understanding the molecular mechanisms by which JNK1 and IKKβ mediate obesity-induced metabolic stress is likely to be of importance for the development of new treatments for a variety of obesity-associated diseases.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301625
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