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Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway

  • Talarek, Nicolas Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Cameroni, Elisabetta Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland - Institute of Cell Biology, University of Bern, Switzerland
  • Jaquenoud, Malika Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Luo, Xuan Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Bontron, Séverine Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Lippman, Soyeon Department of Molecular Biology, Princeton University, USA
  • Devgan, Geeta Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, USA
  • Snyder, Michael Department of Molecular, Cellular, and Developmental Biology, Yale University, New Haven, USA
  • Broach, James R. Department of Molecular Biology, Princeton University, USA
  • De Virgilio, Claudio Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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    13.05.2010
Published in:
  • Molecular Cell. - 2010, vol. 38, no. 3, p. 345-355
English Eukaryotic cell proliferation is controlled by growth factors and essential nutrients, in the absence of which cells may enter into a quiescent (G0) state. In yeast, nitrogen and/or carbon limitation causes downregulation of the conserved TORC1 and PKA signaling pathways and, consequently, activation of the PAS kinase Rim15, which orchestrates G0 program initiation and ensures proper life span by controlling distal readouts, including the expression of specific genes. Here, we report that Rim15 coordinates transcription with posttranscriptional mRNA protection by phosphorylating the paralogous Igo1 and Igo2 proteins. This event, which stimulates Igo proteins to associate with the mRNA decapping activator Dhh1, shelters newly expressed mRNAs from degradation via the 5′-3′ mRNA decay pathway, thereby enabling their proper translation during initiation of the G0 program. These results delineate a likely conserved mechanism by which nutrient limitation leads to stabilization of specific mRNAs that are critical for cell differentiation and life span.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301618
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