Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function
- Reo, Emanuela Department of Zoology and Animal Biology, University of Geneva, Switzerland
- Seum, Carole Department of Zoology and Animal Biology, University of Geneva, Switzerland - Department of Biochemistry, University of Geneva, Switzerland
- Spierer, Pierre Department of Zoology and Animal Biology, University of Geneva, Switzerland
- Bontron, Séverine Department of Zoology and Animal Biology, University of Geneva, Switzerland - Division of Biochemistry, University of Fribourg, Switzerland
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18.03.2010
Published in:
- Nucleic Acids Research. - 2010, vol. 38, no. 13, p. 4254-4262
English
In Drosophila, SU(VAR)3-7 is an essential heterochromatin component. It is required for proper chromatin condensation, and changing its dose modifies position-effect variegation. Sumoylation is a post-translational modification shown to play a role in diverse biological processes. Here, we demonstrate that sumoylation is essential for proper heterochromatin function in Drosophila through modification of SU(VAR)3-7. Indeed, SU(VAR)3-7 is sumoylated at lysine K839; this modification is required for localization of SU(VAR)3-7 at pericentric heterochromatin, chromosome 4, and telomeres. In addition, sumoylation of SU(VAR)3-7 is a prerequisite for its ability to enhance position-effect variegation. Thus, these results show that the heterochromatic function of SU(VAR)3-7 depends on its own sumoylation, and unveil a role for sumoylation in Drosophila heterochromatin.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 18078
- DOI 10.1093/nar/gkq168
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301596
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