Journal article

Sumoylation of Drosophila SU(VAR)3-7 is required for its heterochromatic function

  • Reo, Emanuela Department of Zoology and Animal Biology, University of Geneva, Switzerland
  • Seum, Carole Department of Zoology and Animal Biology, University of Geneva, Switzerland - Department of Biochemistry, University of Geneva, Switzerland
  • Spierer, Pierre Department of Zoology and Animal Biology, University of Geneva, Switzerland
  • Bontron, Séverine Department of Zoology and Animal Biology, University of Geneva, Switzerland - Division of Biochemistry, University of Fribourg, Switzerland
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    18.03.2010
Published in:
  • Nucleic Acids Research. - 2010
English In Drosophila, SU(VAR)3-7 is an essential heterochromatin component. It is required for proper chromatin condensation, and changing its dose modifies position-effect variegation. Sumoylation is a post-translational modification shown to play a role in diverse biological processes. Here, we demonstrate that sumoylation is essential for proper heterochromatin function in Drosophila through modification of SU(VAR)3-7. Indeed, SU(VAR)3-7 is sumoylated at lysine K839; this modification is required for localization of SU(VAR)3-7 at pericentric heterochromatin, chromosome 4, and telomeres. In addition, sumoylation of SU(VAR)3-7 is a prerequisite for its ability to enhance position-effect variegation. Thus, these results show that the heterochromatic function of SU(VAR)3-7 depends on its own sumoylation, and unveil a role for sumoylation in Drosophila heterochromatin.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301596
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