Lipid multilayered particles: the role of chitosan on structure and morphology
- Gerelli, Yuri Dipartimento di Fisica, Università degli Studi di Parma, Italy
- Di Bari, Maria Teresa Dipartimento di Fisica, Università degli Studi di Parma, Italy
- Deriu, Antonio Dipartimento di Fisica, Università degli Studi di Parma, Italy
- Clemens, Daniel Helmholtz-Zentrum Berlin für Materialien und Energie, Berlin, Germany
- Almásy, László Laboratory for Neutron Scattering, PSI and ETH Zürich, Villigen, Switzerland - Adolphe Merkle Institute, University of Fribourg, Switzerland
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2010
Published in:
- Soft Matter. - 2010, vol. 6, p. 2533-2538
English
Multilayered nanovectors made up from a controlled binary lipid mixture (POPC and DMPS) and trimethyl chitosan (TMC) have been prepared and characterized by light- and small angle neutron scattering. The morphology and the multilayer structure of the particle outer shell has been described in detail. By varying the amount of TMC in the starting solution it is possible to tune the overall surface particle charge as well as its multilamellarity. In this way the drug loading/release properties of the particles can be controlled. Therefore the use of controlled POPC/DMPS mixtures can be a valid alternative to commercial lecithin to obtain nanovectors with specific release properties.
- Faculty
- Faculté des sciences et de médecine
- Department
- AMI - Soft Nanoscience
- Language
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- English
- Classification
- Physics
- License
- License undefined
- Identifiers
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- RERO DOC 20885
- DOI 10.1039/b924616a
- Persistent URL
- https://folia.unifr.ch/unifr/documents/301592
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