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Driving ribosome assembly

  • Kressler, Dieter Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany - University of Fribourg, Department of Medicine, Unit of Biochemistry, Switzerland
  • Hurt, Ed Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany
  • Baβler, Jochen Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany
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  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. - 2010, vol. 1803, no. 6, p. 673-683
English Ribosome biogenesis is a fundamental process that provides cells with the molecular factories for cellular protein production. Accordingly, its misregulation lies at the heart of several hereditary diseases (e.g., Diamond-Blackfan anemia). The process of ribosome assembly comprises the processing and folding of the pre-rRNA and its concomitant assembly with the ribosomal proteins. Eukaryotic ribosome biogenesis relies on a large number (> 200) of non-ribosomal factors, which confer directionality and accuracy to this process. Many of these non-ribosomal factors fall into different families of energy-consuming enzymes, notably including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. Ribosome biogenesis is highly conserved within eukaryotic organisms; however, due to the combination of powerful genetic and biochemical methods, it is best studied in the yeast Saccharomyces cerevisiae. This review summarizes our current knowledge on eukaryotic ribosome assembly, with particular focus on the molecular role of the involved energy-consuming enzymes.
Faculté des sciences et de médecine
Département de Biologie
  • English
Biological sciences
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