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Driving ribosome assembly

  • Kressler, Dieter Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany - University of Fribourg, Department of Medicine, Unit of Biochemistry, Switzerland
  • Hurt, Ed Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany
  • Baβler, Jochen Biochemie-Zentrum der Universität Heidelberg, Heidelberg, Germany
    30.10.2009
Published in:
  • Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. - 2010, vol. 1803, no. 6, p. 673-683
Ribosome assembly
Nuclear export of ribosomes
Diamond-Blackfan anemia
Shwachman-Diamond syndrome
Dyskeratosis congenita
Cartilage–hair hypoplasia
Bowen-Conradi syndrome
Cancer
Quality control of ribosomes
English Ribosome biogenesis is a fundamental process that provides cells with the molecular factories for cellular protein production. Accordingly, its misregulation lies at the heart of several hereditary diseases (e.g., Diamond-Blackfan anemia). The process of ribosome assembly comprises the processing and folding of the pre-rRNA and its concomitant assembly with the ribosomal proteins. Eukaryotic ribosome biogenesis relies on a large number (> 200) of non-ribosomal factors, which confer directionality and accuracy to this process. Many of these non-ribosomal factors fall into different families of energy-consuming enzymes, notably including ATP-dependent RNA helicases, AAA-ATPases, GTPases, and kinases. Ribosome biogenesis is highly conserved within eukaryotic organisms; however, due to the combination of powerful genetic and biochemical methods, it is best studied in the yeast Saccharomyces cerevisiae. This review summarizes our current knowledge on eukaryotic ribosome assembly, with particular focus on the molecular role of the involved energy-consuming enzymes.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biological sciences
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/301449
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