Journal article
+ 1 other files
Photoinitiated coupling of unmodified monosaccharides to iron oxide nanoparticles for sensing proteins and bacteria
-
Liu, Li-Hong
Department of Chemistry, Portland State University, USA
-
Dietsch, Hervé
Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
-
Schurtenberger, Peter
Adolphe Merkle Institute and Fribourg Center for Nanomaterials, University of Fribourg, Switzerland
-
Yan, Mingdi
Department of Chemistry, Portland State University, USA
Show more…
Published in:
- Bioconjugate Chemistry. - 2009, vol. 20, no. 7, p. 1349–1355
English
We report a versatile approach for the immobilization of unmodified monosaccharides onto iron oxide nanoparticles. Covalent coupling of the carbohydrate onto iron oxide nanoparticle surfaces was accomplished by the CH insertion reaction of photochemically activated phosphate-functionalized perfluorophenylazides (PFPAs), and the resulting glyconanoparticles were characterized by IR, TGA, and TEM. The surface-bound d-mannose showed the recognition ability toward Concanavalin A and Escherichia coli strain ORN178 that possesses mannose-specific receptor sites. Owing to the simplicity and versatility of the technique, together with the magnetic property of iron oxide nanoparticles, the methodology developed in this study serves as a general approach for the preparation of magnetic glyconanoparticles to be used in clinical diagnosis, sensing, and decontamination.
-
Faculty
- Faculté des sciences et de médecine
-
Department
- AMI - Soft Nanoscience
-
Language
-
-
Classification
-
Biotechnology
-
License
-
License undefined
-
Identifiers
-
-
Persistent URL
-
https://folia.unifr.ch/unifr/documents/301347
Other files
Statistics
Document views: 39
File downloads:
- schurtenberger_pcu.pdf: 56
- schurtenberger_pcu_sm.pdf: 46