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Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression

  • Ming, Xiu-Fen Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Rajapakse, Angana Gupta Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Carvas, João Miguel Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Ruffieux, Jean Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Yang, Zhihong Division of Physiology, Department of Medicine, University of Fribourg, Switzerland
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    13.11.2009
Published in:
  • Febs Letters. - 2010, vol. 58, no. 1, p. 135-140
English Rapamycin has been reported to enhance tissue factor (TF) expression. The present study investigated roles of mammalian target of rapamycin (mTOR) and its downstream S6K1 in this process. We showed here that, consistent with rapamycin, knocking-down mTOR enhanced thrombin-induced TF mRNA and protein levels, whereas silencing S6K1 mitigated up-regulation of TF protein but not TF mRNA level. The enhanced TF protein level upon mTOR-silencing was further augmented by over-expression of a constitutively active S6K1 mutant and reduced by blocking RhoA, p38mapk or NF-κB. The results reveal an opposing and uncoupling effect of mTOR and S6K1 in regulating TF expression.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301298
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