Journal article

+ 1 other files

Fitness differences associated with Pgi SNP genotypes in the Glanville fritillary butterfly (Melitaea cinxia)

  • Orsini, L. Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, Finland
  • Wheat, C. W. Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, Finland - Department of Biology, Penn State University, USA
  • Haag, Christoph R. Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, Finland - Department of Biology, University of Fribourg, Switzerland
  • Kvist, J. Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, Finland - Institute of Biotechnology, University of Helsinki, Helsinki, Finland
  • Frilander, M. J. Institute of Biotechnology, University of Helsinki, Helsinki, Finland
  • Hanski, I. Metapopulation Research Group, Department of Biological and Environmental Sciences, University of Helsinki, Finland
Show more…
    20.10.2008
Published in:
  • Journal of Evolutionary Biology. - 2009, vol. 22, no. 2, p. 367-375
English llozyme variation at the phosphoglucose isomerase (PGI) locus in the Glanville fritillary butterfly (Melitaea cinxia) is associated with variation in flight metabolic rate, dispersal rate, fecundity and local population growth rate. To map allozyme to DNA variation and to survey putative functional variation in genomic DNA, we cloned the coding sequence of Pgi and identified nonsynonymous variable sites that determine the most common allozyme alleles. We show that these single-nucleotide polymorphisms (SNPs) exhibit significant excess of heterozygotes in field-collected population samples as well as in laboratory crosses. This is in contrast to previous results for the same species in which other allozymes and SNPs were in Hardy–Weinberg equilibrium or exhibited an excess of homozygotes. Our results suggest that viability selection favours Pgi heterozygotes. Although this is consistent with direct overdominance at Pgi, we cannot exclude the possibility that heterozygote advantage is caused by the presence of one or more deleterious alleles at linked loci.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology, life sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/301290
Other files

Statistics

Document views: 6 File downloads:
  • hagg_fda.pdf: 1
  • hagg_fda_sm.pdf: 2