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Cellular toxicity of TiO₂-based nanofilaments

  • Magrez, Arnaud Institute of Physics of Condensed Matter (IPMC), Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Horvth, Lenke Institute of Physics of Condensed Matter (IPMC), Ecole Polytechnique Fédérale de Lausanne, Switzerland - Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Smajda, Rita Institute of Physics of Condensed Matter (IPMC), Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Salicio, Valérie Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Pasquier, Nathalie Laboratoire Cytopath, Avenue Cardinal-Mermillod, Genève-Carouge, Switzerland
  • Forró, László Institute of Physics of Condensed Matter (IPMC), Ecole Polytechnique Fédérale de Lausanne, Switzerland
  • Schwaller, Beat Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
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    17.07.2009
Published in:
  • ACS Nano. - 2009, vol. 3, no. 8, p. 2274–2280
English At present, nanofilaments are not exclusively based on carbon atoms but can be produced from many inorganic materials in the form of nanotubes and nanowires. It is essential to systematically assess the acute toxicity of these newly synthesized materials since it cannot be predicted from the known toxicity of the same material in another form. Here, the cellular toxicity of TiO₂-based nanofilaments was studied in relation to their morphology and surface chemistry. These structures produced by hydrothermal treatment were titanate nanotubes and nanowires with a NaxTiO2+δ composition. The cytotoxic effect was mainly evaluated by MTT assays combined with direct cell counting and cytopathological analyses of the lung tumor cells. Our work clearly demonstrated that the presence of NaxTiO2+δ nanofilaments had a strong dose-dependent effect on cell proliferation and cell death. Nanofilament internalization and alterations in cell morphology were observed. Acid treatment performed to substitute Na⁺ with H⁺ in the NaxTiO2+δ nanofilaments strongly enhanced the cytotoxic action. This effect was attributed to structural imperfections, which are left by the atom diffusion during the substitution. On the basis of our findings, we conclude that TiO₂-based nanofilaments are cytotoxic and thus precautions should be taken during their manipulation.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/301205
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