Journal article

Combating implant infections. Remarks by a women’s team

  • Arciola, C. R. Research Unit on Implant Infections, Rizzoli Orthopedic Institute and Experimental Pathology Department, University of Bologna, Bologna - Italy
  • Balaban, N. Department of Biomedical Sciences, Tufts University Cummings School of Veterinary Medicine, North Grafton, Massachusetts - USA
  • Baldassarri, L. Department of Infectious, Parasitic and Immunomediated Diseases, National Institute of Health, Rome - Italy
  • Fromm, Katharina M. Chemistry Department, University of Fribourg, Fribourg - Switzerland
  • Hänsch, G. M. Institute for Immunology of the University of Heidelberg, Heidelberg - Germany
  • Obst, U. Department of Environmental Microbiology, Institute for Technical Chemistry-Water Technology and Geotechnology, Eggenstein-Leopoldshafen - Germany
  • Presterl, E. Department of Medicine I, Division of Infectious Diseases and Tropical Medicine, University of Vienna, Vienna - Austria
  • Stefani, S. Department of Microbiological and Gynecological Sciences, University of Catania, Catania - Italy
  • Verran, J. Manchester Metropolitan University, Manchester - United Kingdom
  • Visai, L. University of Pavia, Department of Biochemistry, Pavia - Italy
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  • The International Journal of Artificial Organs. - 2008, vol. 31, p. 858 - 864
English Research on implant infections requires cooperative efforts and integration between basic and clinical expertises. An international group of women scientists is acting together in this field. The main research topics of the participants of this group are described. Formation of bacterial biofilms, antibiotic resistance and production of virulence factors like adhesins and toxins are investigated. New biomaterials, coatings and drugs designed to inhibit microbial adhesion are evaluated, and infection-resistant biomaterials are under study, such as a novel heparinizable polycarbonate-urethane (Bionate) or incorporation of diamino-diamide-diol (PIME) to reduce bacterial attachment. The correlation between biofilm production and the accessory-gene-regulator (agr) is investigated in Staphylococcus aureus. The ability to form biofilm has also been shown to be one of the important virulence factors of Enterococcus faecalis, favouring colonization of inert and biological surfaces. The study of quorum sensing has led to the discovery of a quorum sensing inhibitor termed RIP that suppresses staphylococcal biofilm and infections. The immune response and the local defence mechanisms of the host against implant-associated infections, activation and infiltration of immunocompetent cells into the sites of infection have been studied in patients with implant-associated osteomyelitis. Production of monoclonal antibodies (mAbs) as possible vaccines against the staphylococcal collagen-binding MSCRAMMs is in progress.
Faculté des sciences et de médecine
Département de Chimie
  • English
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  • RERO DOC 12243
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