Journal article

Nanodomain coupling between Ca2+ channels and Ca2+ sensors promotes fast and efficient transmitter release at a cortical GABAergic synapse

  • Bucurenciu, Iancu Physiological Institute I, University of Freiburg, Germany
  • Kulik, Akos Institute of Anatomy and Cell Biology, University of Freiburg, Germany
  • Schwaller, Beat Unit of Anatomy, Department of Medicine, University of Fribourg, Switzerland
  • Frotscher, Michael Institute of Anatomy and Cell Biology, University of Freiburg, Germany
  • Jonas, Peter Physiological Institute I, University of Freiburg, Germany
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    27.02.2008
Published in:
  • Neuron. - 2008, vol. 57, no. 4, p. 536-545
English It is generally thought that transmitter release at mammalian central synapses is triggered by Ca²⁺ microdomains, implying loose coupling between presynaptic Ca²⁺ channels and Ca²⁺ sensors of exocytosis. Here we show that Ca²⁺ channel subunit immunoreactivity is highly concentrated in the active zone of GABAergic presynaptic terminals of putative parvalbumin-containing basket cells in the... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300666