Renal expression of parvalbumin is critical for NaCl handling and response to diuretics
- Belge, Hendrica Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
- Gailly, Philippe Departments of Physiology, Université Catholique de Louvain Medical School, Brussels, Belgium
- Schwaller, Beat Unit of Anatomy, University of Fribourg, Switzerland
- Loffing, Johannes Unit of Anatomy, University of Fribourg, Switzerland
- Debaix, Huguette Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
- Riveira-Munoz, Eva Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
- Beauwens, Renaud Laboratory of Cell and Molecular Physiology, Université Libre de Bruxelles Medical School, Brussels, Belgium
- Devogelaer, Jean-Pierre Departments of Rheumatology, Université Catholique de Louvain Medical School, Brussels, Belgium
- Hoenderop, Joost G. Department of Physiology, Radboud University Nijmegen, The Netherlands
- Bindels, René J. Department of Physiology, Radboud University Nijmegen, The Netherlands
- Devuyst, Olivier Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
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05.09.2007
Published in:
- Proceedings of the National Academy of Sciences of the United States of America. - 2007, vol. 104, no. 37, p. 14849-14854
English
The distal convoluted tubule (DCT) plays an essential role in the reabsorption of NaCl by the kidney, a process that can be inhibited by thiazide diuretics. Parvalbumin (PV), a Ca²⁺-binding protein that plays a role in muscle fibers and neurons, is selectively expressed in the DCT, where its role remains unknown. We therefore investigated the renal phenotype of PV knockout mice... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 8477
- DOI 10.1073/pnas.0702810104
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300617