Journal article

Renal expression of parvalbumin is critical for NaCl handling and response to diuretics

  • Belge, Hendrica Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
  • Gailly, Philippe Departments of Physiology, Université Catholique de Louvain Medical School, Brussels, Belgium
  • Schwaller, Beat Unit of Anatomy, University of Fribourg, Switzerland
  • Loffing, Johannes Unit of Anatomy, University of Fribourg, Switzerland
  • Debaix, Huguette Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
  • Riveira-Munoz, Eva Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
  • Beauwens, Renaud Laboratory of Cell and Molecular Physiology, Université Libre de Bruxelles Medical School, Brussels, Belgium
  • Devogelaer, Jean-Pierre Departments of Rheumatology, Université Catholique de Louvain Medical School, Brussels, Belgium
  • Hoenderop, Joost G. Department of Physiology, Radboud University Nijmegen, The Netherlands
  • Bindels, René J. Department of Physiology, Radboud University Nijmegen, The Netherlands
  • Devuyst, Olivier Departments of Nephrology, Université Catholique de Louvain Medical School, Brussels, Belgium
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    05.09.2007
Published in:
  • Proceedings of the National Academy of Sciences of the United States of America. - 2007, vol. 104, no. 37, p. 14849-14854
English The distal convoluted tubule (DCT) plays an essential role in the reabsorption of NaCl by the kidney, a process that can be inhibited by thiazide diuretics. Parvalbumin (PV), a Ca²⁺-binding protein that plays a role in muscle fibers and neurons, is selectively expressed in the DCT, where its role remains unknown. We therefore investigated the renal phenotype of PV knockout mice... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300617