Journal article

Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK

  • Langmesser, Sonja Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
  • Tallone, Tiziano Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland - PolyGene AG, Rümlang, Switzerland
  • Bordon, Alain Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland - Friedrich Miescher Institute for Biomedical Research, Novartis Research Foundation, Basel, Switzerland
  • Rusconi, Sandro Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland - Dipartimento dell’educazione, della cultura e dello sport, Bellinzona, Switzerland
  • Albrecht, Urs Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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    22.04.2008
Published in:
  • BMC Molecular Biology. - 2008, vol. 9, p. 41
English Background: Circadian oscillation of clock-controlled gene expression is mainly regulated at the transcriptional level. Heterodimers of CLOCK and BMAL1 act as activators of target gene transcription; however, interactions of PER and CRY proteins with the heterodimer abolish its transcriptional activation capacity. PER and CRY are therefore referred to as negative regulators of the circadian... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300596