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Induction of Ucp2 expression in brain phagocytes and neurons following murine toxoplasmosis: An essential role of IFN-γ and an association with negative energy balance

  • Arsenijevic, Denis Department of Medicine, Division of Physiology, University of Fribourg, Switzerland
  • Clavel, Sébastien Centre de recherche de l'Hôpital Laval, Sainte-Foy (Québec), Canada
  • Sanchis, Daniel Centre National de la Recherche Scientifique, Faculté de médecine Necker-Enfants Malades, Paris, France
  • Plamondon, Julie Centre de recherche de l'Hôpital Laval, Sainte-Foy (Québec), Canada
  • Huang, Quingling Centre de recherche de l'Hôpital Laval, Sainte-Foy (Québec), Canada
  • Ricquier, Daniel Centre National de la Recherche Scientifique, Faculté de médecine Necker-Enfants Malades, Paris, France
  • Rouger, Laurie Centre de recherche de l'Hôpital Laval, Sainte-Foy (Québec), Canada
  • Richard, Denis Centre de recherche de l'Hôpital Laval, Sainte-Foy (Québec), Canada
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    30.04.2007
Published in:
  • Journal of Neuroimmunology. - 2007, vol. 186, no. 1-2, p. 121-132
uncoupling-protein-2
toxoplasmosis
brain
neuron
microglia
interferon-gamma
English A model of murine toxoplasmosis was used to study cellular and temporal expression of uncoupling protein-2 (Ucp2) in the brain. In situ hybridization indicated that Ucp2 was located in neurons. Nuclei structures involved in energy balance, in particular the nucleus of the solitary tract (NST), was shown to have a positive association between negative energy balance and Ucp2 levels. Infection-induced Ucp2 expression colocalized mainly with microglial cells, but also with infiltrating macrophages and neutrophils in the brain, which was evident from day 9 post-infection. Using cytokine knockout mice we demonstrate that microglial Ucp2 induction in the brain was largely dependant on interferon-γ, but not interleukin-6 or tumour-necrosis-factor-α in response to infection. In summary, this study shows that Ucp2 is regulated in a different manner in neurons than in microglia/phagocytes following infection. Our study indicates that an association exists between negative energy balance and neuronal Ucp2 levels in the NST, in particular.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biological sciences
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300577
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