Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion
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Beaud, Marie-Laure
Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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Schmidlin, Eric
Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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Wannier, Thierry
Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland - Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
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Freund, Patrick
Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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Bloch, Jocelyne
Dept. of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
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Mir, Anis
Neuroscience Research, Novartis Institute for BioMedical Research, Basel, Switzerland
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Schwab, Martin E.
Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
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Rouiller, Eric M.
Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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Published in:
- BMC Neuroscience. - 2008, vol. 9, no. 1, p. 5
English
Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS... Show more…
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Médecine
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Language
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Classification
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Biology
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/300482