Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion
- Beaud, Marie-Laure Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
- Schmidlin, Eric Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
- Wannier, Thierry Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland - Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
- Freund, Patrick Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
- Bloch, Jocelyne Dept. of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
- Mir, Anis Neuroscience Research, Novartis Institute for BioMedical Research, Basel, Switzerland
- Schwab, Martin E. Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
- Rouiller, Eric M. Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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14.01.2008
Published in:
- BMC Neuroscience. - 2008, vol. 9, no. 1, p. 5
English
Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 8884
- DOI 10.1186/1471-2202-9-5
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300482