Journal article

Anti-Nogo-A antibody treatment does not prevent cell body shrinkage in the motor cortex in adult monkeys subjected to unilateral cervical cord lesion

  • Beaud, Marie-Laure Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
  • Schmidlin, Eric Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
  • Wannier, Thierry Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland - Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
  • Freund, Patrick Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
  • Bloch, Jocelyne Dept. of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
  • Mir, Anis Neuroscience Research, Novartis Institute for BioMedical Research, Basel, Switzerland
  • Schwab, Martin E. Brain Research Institute, Dept. Neuromorphology, University and ETH Zurich, Switzerland
  • Rouiller, Eric M. Unit of Physiology and Program in Neurosciences, Department of Medicine, University of Fribourg, Switzerland
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    14.01.2008
Published in:
  • BMC Neuroscience. - 2008, vol. 9, no. 1, p. 5
English Background: After unilateral cervical cord lesion at the C7/C8 border interrupting the dorsolateral funiculus in adult monkeys, neutralization of Nogo-A using a specific monoclonal antibody promoted sprouting of corticospinal (CS) axons rostral and caudal to the lesion and, in parallel, improved functional recovery. In monkeys lesioned but not treated with the anti-Nogo-A antibody, the CS... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300482