Journal article

TNF-α suppresses the expression of clock genes by interfering with E-box-mediated transcription

  • Cavadini, Gionata Division of Clinical Immunology, University Hospital Zurich, Switzerland
  • Petrzilka, Saskia Division of Clinical Immunology, University Hospital Zurich, Switzerland
  • Kohler, Philipp Division of Clinical Immunology, University Hospital Zurich, Switzerland
  • Jud, Corinne Institute of Biochemistry, University of Fribourg, Switzerland
  • Tobler, Irene Institute of Pharmacology and Toxicology, University of Zurich, Switzerland
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    23.06.2007
Published in:
  • Proceedings of the National Academy of Sciences of the United States of America. - 2007, vol. 104, no. 31, p. 12843-12848
English Production of TNF-α and IL-1 in infectious and autoimmune diseases is associated with fever, fatigue, and sleep disturbances, which are collectively referred to as sickness behavior syndrome. In mice TNF-α and IL-1 increase nonrapid eye movement sleep. Because clock genes regulate the circadian rhythm and thereby locomotor activity and may alter sleep architecture we assessed the influence of... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300468