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Direct comparison between properties of adaptation of the auditory nerve and the ventral cochlear nucleus in response to repetitive clicks

  • Meyer, Kaspar Unit of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Rouiller, Eric M. Unit of Physiology, Department of Medicine, University of Fribourg, Switzerland
  • Loquet, Gérard Unit of Physiology, Department of Medicine, University of Fribourg, Switzerland
    22.02.2007
Published in:
  • Hearing Research. - 2007, vol. 228, no. 1-2, p. 144-155
Auditory evoked potentials
Brainstem
click
rat
unanaesthetized
English The present study was designed to complete two previous reports [Loquet, G., Rouiller, E.M., 2002. Neural adaptation to pulsatile acoustical stimulation in the cochlear nucleus of the rat. Hear. Res. 171, 72–81; Loquet, G., Meyer, K., Rouiller, E.M., 2003. Effects of intensity of repetitive acoustic stimuli on neural adaptation in the ventral cochlear nucleus of the rat. Exp. Brain Res. 153, 436–442] on neural adaptation properties in the auditory system of the rat. Again, auditory near-field evoked potentials (ANEPs) were recorded in response to 250-ms trains of clicks from an electrode chronically implanted in the ventral cochlear nucleus (VCN). Up to now, our interest had focused on the adaptive behavior of the first one (N₁) of the two negative ANEP components. A re-examination of our data for the second negative component (N₂) was now undertaken. Results show that the adaptation time course observed for N₂ displayed the same three-stage pattern previously reported for N₁. Similarly, adaptation became more pronounced and occurred faster as stimulus intensity and/or repetition rate were increased. Based on latency data which suggest N₁ and N₂ to be mainly due to the activity of auditory-nerve (AN) fibers and cochlear nucleus neurons, respectively, it was concluded that neural adaptation assessed by gross-potentials was similar in the AN and VCN. This finding is meaningful in the context of our search to restore normal adaptation phenomena via electro-auditory hearing with an auditory brainstem implant on the same lines as our work in cochlear implants.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biological sciences
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/300339
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