Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey
- Freund, Patrick Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
- Wannier, Thierry Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland - Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
- Schmidlin, Eric Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
- Bloch, Jocelyne Department of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
- Mir, Anis Novartis Institute for Biomedical Research, Basel, Switzerland
- Schwab, Martin E. Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
- Rouiller, Eric M. Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
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29.03.2007
Published in:
- The Journal of Comparative Neurology. - 2007, vol. 502, no. 4, p. 644 - 659
English
After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 8153
- DOI 10.1002/cne.21321
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300310