Journal article

Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey

  • Freund, Patrick Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
  • Wannier, Thierry Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland - Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
  • Schmidlin, Eric Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
  • Bloch, Jocelyne Department of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
  • Mir, Anis Novartis Institute for Biomedical Research, Basel, Switzerland
  • Schwab, Martin E. Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
  • Rouiller, Eric M. Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
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    29.03.2007
Published in:
  • The Journal of Comparative Neurology. - 2007, vol. 502, no. 4, p. 644 - 659
English After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a... Show more…
Faculty
Faculté des sciences
Department
Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300310