Anti-Nogo-A antibody treatment enhances sprouting of corticospinal axons rostral to a unilateral cervical spinal cord lesion in adult macaque monkey
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Freund, Patrick
Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
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Wannier, Thierry
Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland - Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
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Schmidlin, Eric
Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
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Bloch, Jocelyne
Department of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Switzerland
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Mir, Anis
Novartis Institute for Biomedical Research, Basel, Switzerland
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Schwab, Martin E.
Brain Research Institute, Department of Neuromorphology, University and ETH Zurich, Switzerland
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Rouiller, Eric M.
Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland
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Published in:
- The Journal of Comparative Neurology. - 2007, vol. 502, no. 4, p. 644 - 659
English
After injury, regrowth of axons in mammalian adult central nervous system is highly limited. However, in monkeys subjected to unilateral cervical lesion (C7-C8 level), neutralization of an important neurite outgrowth inhibitor, Nogo-A, stimulated axonal sprouting caudal to the lesion, accompanied by enhanced functional recovery of manual dexterity, compared with lesioned monkeys treated with a... Show more…
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Médecine
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Language
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Classification
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Biology
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/300310