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Telmisartan prevents the glitazone-induced weight gain without interfering with its insulin-sensitizing properties

  • Zanchi, Anne Division of Nephrology and Department of Medicine, CHUV and University of Lausanne, Switzerland
  • Dulloo, Abdul G. Division of Physiology, University of Fribourg, Switzerland
  • Perregaux, Christine Division of Nephrology and Department of Medicine, CHUV and University of Lausanne, Switzerland
  • Montani, Jean-Pierre Division of Physiology, University of Fribourg, Switzerland
  • Burnier, Michel Division of Nephrology and Department of Medicine, CHUV and University of Lausanne, Switzerland
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    20.03.2007
Published in:
  • American Journal of Physiology - Endocrinology and Metabolism. - 2007, vol. 293, p. E91-E95
glitazones
fat
angiotensin II receptor blocker
English Glitazones are peroxisome proliferator-activated receptor (PPAR)-Γ agonists with powerful insulin-sensitizing properties. They promote the development of metabolically active adipocytes that can lead to a substantial gain in fat mass. Telmisartan is an ANG II type 1 receptor antagonist with partial PPAR-Γ agonistic properties. Recently, telmisartan has been reported to prevent weight gain and improve insulin sensitivity in diet-induced obese rodents. The goal of this study was to examine the influence of telmisartan on pioglitazone-induced weight gain and insulin-sensitizing properties in the following two models of insulin resistance: a nongenetic model (high-fat-fed Sprague Dawley rats) and the genetically obese fa/fa Zucker rat. After a 4-wk treatment, the pioglitazone-induced increase in fat mass was modest in the Sprague Dawley rats and severe in the Zucker rats. In both models, these effects were substantially decreased by concomitant treatment with telmisartan. The effects of telmisartan on body weight and fat mass in the Zucker rats were abolished by pair feeding, suggesting that it is the result of a decrease in food intake. Telmisartan did not interfere with the insulin-sensitizing properties of pioglitazone. This study demonstrates that telmisartan attenuates the glitazone-induced increase in fat mass without interfering with its insulin-sensitizing properties.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Medicine
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/300302
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