Doxycycline reduces mortality and injury to the brain and cochlea in experimental pneumococcal meningitis
- Meli, Damian N. Institute for Infectious Diseases, University of Bern, Switzerland
- Coimbra, Roney S. Institute for Infectious Diseases, University of Bern, Switzerland
- Erhart, Dominik G. Institute for Infectious Diseases, University of Bern, Switzerland
- Loquet, Gérard Department of Medicine, Unit of Physiology, University of Fribourg, Switzerland
- Bellac, Caroline L. Institute for Infectious Diseases, University of Bern, Switzerland
- Täuber, Martin G. Institute for Infectious Diseases, University of Bern, Switzerland
- Neumann, Ulf Novartis Institute for Biomedical Research, Basel, Switzerland
- Leib, Stephen L. Institute for Infectious Diseases, University of Bern, Switzerland
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2006
Published in:
- Infection and Immunity. - 2006, vol. 74, no. 7, p. 3890-3896
English
Bacterial meningitis is characterized by an inflammatory reaction to the invading pathogens that can ultimately lead to sensorineural hearing loss, permanent brain injury, or death. The matrix metalloproteinases (MMPs) and tumor necrosis factor alpha-converting enzyme (TACE) are key mediators that promote inflammation, blood-brain barrier disruption, and brain injury in bacterial meningitis.... Show more…
- Faculty
- Faculté des sciences
- Department
- Médecine
- Language
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- English
- Classification
- Medicine
- License
- License undefined
- Identifiers
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- RERO DOC 5961
- DOI 10.1128/IAI.01949-05
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300185