Long-term gene silencing by RNAi
- Vastenhouw, Nadine L. Hubrecht Laboratory–KNAW, University of Utrecht, the Netherlands
- Brunschwig, Karin Institute of Zoology, University of Fribourg, Switzerland
- Okihara, Kristy L. Hubrecht Laboratory–KNAW, University of Utrecht, the Netherlands
- Müller, Fritz Institute of Zoology, University of Fribourg, Switzerland
- Tijsterman, Marcel Hubrecht Laboratory–KNAW, University of Utrecht, the Netherlands
- Plasterk, Ronald H. A. Hubrecht Laboratory–KNAW, University of Utrecht, the Netherlands - University of Utrecht, the Netherlands
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23.08.2006
English
Small RNA molecules participate in a variety of activities in the cell: in a process known as RNA interference (RNAi), double-stranded RNA triggers the degradation of messenger RNA that has a matching sequence; the small RNA intermediates of this process can also modify gene expression in the nucleus¹. Here we show that a single episode of RNAi in the nematode Caenorhabditis elegans can induce transcriptional silencing effects that are inherited indefinitely in the absence of the original trigger. Our findings may prove useful in the ongoing development of RNAi to treat disease.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biological sciences
- License
- License undefined
- Identifiers
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- RERO DOC 5960
- DOI 10.1038/442882a
- Persistent URL
- https://folia.unifr.ch/unifr/documents/300141
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