Journal article

Ablation of the single dynamin of T. brucei blocks mitochondrial fission and endocytosis and leads to a precise cytokinesis arrest

  • Chanez, Anne-Laure Department of Biology, Cell and Developmental Biology, University of Fribourg, Switzerland
  • Hehl, Adrian B. Institute of Parasitology, University of Zurich, Switzerland
  • Engstler, Markus Ludwig-Maximilians-Universität, Department Biologie I, Genetik, München, Germany
  • Schneider, André Department of Biology, Cell and Developmental Biology, University of Fribourg, Switzerland
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    20.06.2006
Published in:
  • Journal of Cell Science. - 2006, vol. 119, p. 2968-2974
English Mitochondrial fission is mediated by dynamin-like proteins (DLPs). <i>Trypanosoma brucei</i> contains a single DLP, which is the only member of the dynamin superfamily. We have previously shown that expression of the human proapoptotic Bax in <i>T. brucei</i> induces extensive mitochondrial fragmentation. Here we report that Baxinduced mitochondrial fission is abolished in cell lines lacking... Show more…
Faculty
Faculté des sciences
Department
Biologie
Language
  • English
Classification
Biology
Other electronic version

Supplementary material : http://jcs.biologists.org/cgi/content/full/119/14/2968/DC1

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Persistent URL
https://folia.unifr.ch/unifr/documents/300095