Preprint

Nogo-A–specific antibody treatment enhances sprouting and functional recovery after cervical lesion in adult primates

  • Freund, Patrick Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland.
  • Schmidlin, Eric Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland.
  • Wannier, Thierry Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland. - Brain Research Institute, University of Zürich, Department of Biology, ETH Zürich, Switzerland.
  • Bloch, Jocelyne Department of Neurosurgery, Neurosurgery Clinic, University Hospital of Lausanne, Lausanne, Switzerland.
  • Mir, Anis Neuroscience Research, Novartis Institute for BioMedical Research, Basel, Switzerland.
  • Schwab, Martin E. Brain Research Institute, University of Zürich, Department of Biology, ETH Zürich, Switzerland.
  • Rouiller, Eric M. Unit of Physiology and Program in Neurosciences, Department of Medicine, Faculty of Sciences, University of Fribourg, Switzerland.
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    2006

3

English In rodents, after spinal lesion, neutralizing the neurite growth inhibitor Nogo-A promotes axonal sprouting and functional recovery. To evaluate this treatment in primates, 12 monkeys were subjected to cervical lesion. Recovery of manual dexterity and sprouting of corticospinal axons were enhanced in monkeys treated with Nogo-A– specific antibody as compared to monkeys treated with control antibody. Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Medicine
Other electronic version

Video sequences : http://www.unifr.ch/neuro/rouiller/motorcontcadre.htm

License
License undefined
Identifiers
  • RERO DOC 5830
Persistent URL
https://folia.unifr.ch/unifr/documents/300071