Journal article

Electrostatic control on endo/exo selectivity in ionic cycloaddition

  • Tamilmani, Venkatachalam Department of Chemistry, University of Fribourg, Switzerland - Department of Chemistry, Bharathidasan University, Tiruchirappalli, India
  • Daul, Claude Department of Chemistry, University of Fribourg, Switzerland
  • Venuvanalingam, P. Department of Chemistry, Bharathidasan University, Tiruchirappalli, India
    18.10.2005
Published in:
  • Chemical Physics Letters. - 2005, vol. 416(4-6), no. 354
English DFT method has been used in combination with various basis sets to model the ionic cycloaddition of cationic heteroaromatic diene, 2,3-dimethylisoquinoliniuim ion with cyclopentadiene with a view to understand the factors that influence the stereochemical outcome of the reaction. Calculations show that this reaction is an inverse electron demand type reaction and it passes through highly asynchronous transition states and mainly electrostatic repulsion govern the endo/exo selectivity of the reaction. Endo TS is more destabilized than exo TS due to repulsion between positive charges delocalized over the two reacting partners in the transition state and hence, exo adduct is more preferred than endo adduct in total agreement with experiment.
Faculty
Faculté des sciences et de médecine
Department
Département de Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/300062
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