Rhythmic CLOCK-BMAL1 binding to multiple E-box motifs drives circadian Dbp transcription and chromatin transitions
- Ripperger, Jürgen A. Department of Molecular Biology and National Center of Competence in Research 'Frontiers in Genetics', Sciences III, University of Geneva, Geneva, Switzerland - Section of Biochemistry, Department of Medicine, University of Fribourg, Switzerland
- Schibler, Ueli Department of Molecular Biology and National Center of Competence in Research 'Frontiers in Genetics', Sciences III, University of Geneva, Geneva, Switzerland
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2006
Published in:
- Nature Genetics. - 2006, vol. 38, p. 369-374
English
Mammalian circadian rhythms are based on transcriptional and post-translational feedback loops. Essentially, the activity of the transcription factors BMAL1 (also known as MOP3) and CLOCK is rhythmically counterbalanced by Period (PER) and Cryptochrome (CRY) proteins to govern time of day–dependent gene expression1. Here we show that circadian regulation of the mouse albumin D element–binding... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Biologie
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 5812
- DOI 10.1038/ng1738
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299950