Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans
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Cajochen, Christian
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, Switzerland
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Jud, Corinne
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Münch, Mirjam
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, Switzerland
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Kobialka, Szymon
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, Switzerland
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Wirz-Justice, Anna
Centre for Chronobiology, Psychiatric University Clinics, University of Basel, Switzerland
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Albrecht, Urs
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Published in:
- European Journal of Neuroscience. - 2006, vol. 23, no. 4, p. 1082-1086
English
We developed a non-invasive method to measure and quantify human circadian PER2 gene expression in oral mucosa samples and show that this gene oscillates in a circadian (= about a day) fashion. We also have the first evidence that induction of human PER2 expression is stimulated by exposing subjects to 2 h of light in the evening. This increase in PER2 expression was statistically significant in comparison to a non-light control condition only after light at 460 nm (blue) but not after light exposure at 550 nm (green). Our results indicate that the non-image-forming visual system is involved in human circadian gene expression. The demonstration of a functional circadian machinery in human buccal samples and its response to light opens the door for investigation of human circadian rhythms at the gene level and their associated disorders.
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Biologie
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/299914
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