Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism
- Michlig, Stéphanie Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
- Harris, Michael Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
- Loffing, Johannes Département de Médicine, Unité d'Anatomie, Université de Fribourg, Switzerland
- Rossier, Bernard C. Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
- Firsov, Dmitri Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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19.09.2005
Published in:
- Journal of Biological Chemistry. - 2005, vol. 280, no. 46, p. 38264-38270
English
Activation of the mitogen-activated protein (MAP) kinase cascade by progesterone in <i>Xenopus</i> oocytes leads to a marked down-regulation of activity of the amiloride-sensitive epithelial sodium channel (ENaC). Here we have studied the signaling pathways involved in progesterone effect on ENaC activity. We demonstrate that: (i) the truncation of the C termini of the αβγENaC subunits... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 5440
- DOI 10.1074/jbc.M506308200
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299883