Journal article

Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism

  • Michlig, Stéphanie Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
  • Harris, Michael Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
  • Loffing, Johannes Département de Médicine, Unité d'Anatomie, Université de Fribourg, Switzerland
  • Rossier, Bernard C. Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
  • Firsov, Dmitri Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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    19.09.2005
Published in:
  • Journal of Biological Chemistry. - 2005, vol. 280, no. 46, p. 38264-38270
English Activation of the mitogen-activated protein (MAP) kinase cascade by progesterone in <i>Xenopus</i> oocytes leads to a marked down-regulation of activity of the amiloride-sensitive epithelial sodium channel (ENaC). Here we have studied the signaling pathways involved in progesterone effect on ENaC activity. We demonstrate that: (i) the truncation of the C termini of the αβγENaC subunits... Show more…
Faculty
Faculté des sciences et de médecine
Department
Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299883