Progesterone down-regulates the open probability of the amiloride-sensitive epithelial sodium channel via a Nedd4-2-dependent mechanism
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Michlig, Stéphanie
Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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Harris, Michael
Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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Loffing, Johannes
Département de Médicine, Unité d'Anatomie, Université de Fribourg, Switzerland
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Rossier, Bernard C.
Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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Firsov, Dmitri
Département de Pharmacologie et de Toxicologie, Université de Lausanne, Switzerland
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Published in:
- Journal of Biological Chemistry. - 2005, vol. 280, no. 46, p. 38264-38270
English
Activation of the mitogen-activated protein (MAP) kinase cascade by progesterone in <i>Xenopus</i> oocytes leads to a marked down-regulation of activity of the amiloride-sensitive epithelial sodium channel (ENaC). Here we have studied the signaling pathways involved in progesterone effect on ENaC activity. We demonstrate that: (i) the truncation of the C termini of the αβγENaC subunits... Show more…
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Faculty
- Faculté des sciences et de médecine
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Department
- Médecine
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Language
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Classification
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Biology
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/299883