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Journal article

Divergence and convergence of thalamocortical projections to premotor and supplementary motor cortex: a multiple tracing study in the macaque monkey

  • Morel, Anne Laboratory for Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zürich, Zürich, Switzerland
  • Liu, Jian Laboratory for Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zürich, Zürich, Switzerland
  • Wannier, Thierry Unit of Physiology, Department of Medicine and Program in Neuroscience, University of Fribourg, Switzerland
  • Jeanmonod, Daniel Laboratory for Functional Neurosurgery, Neurosurgery Clinic, University Hospital Zürich, Zürich, Switzerland
  • Rouiller, Eric M. Unit of Physiology, Department of Medicine and Program in Neuroscience, University of Fribourg, Switzerland
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    07.03.2005
Published in:
  • European Journal of Neuroscience. - 2005, vol. 21, no. 4, p. 1007-1029
English The premotor cortex of macaque monkeys is currently subdivided into at least six different subareas on the basis of structural, hodological and physiological criteria. To determine the degree of divergence/convergence of thalamocortical projections to mesial [supplementary motor area (SMA)-proper and pre-SMA] and lateral (PMd-c, PMd-r, PMv-c and PMv-r) premotor (PM) subareas, quantitative analyses were performed on the distribution of retrograde labelling after multiple tracer injections in the same animal. The results demonstrate that all PM and SMA subareas receive common inputs from several thalamic nuclei, but the relative contribution of these nuclei to thalamocortical projections differs. The largest difference occurs between subareas of SMA, with much greater contribution from the mediodorsal (MD) and area X, and a smaller contribution from the ventral lateral anterior (VLa) and ventral part of the ventral lateral posterior (VLpv) to pre-SMA than to SMA-proper. In PM, differences between subareas are less pronounced; in particular, all receive a significant contribution from MD, the ventral anterior (VApc) and area X. However, there are clear gradients, such as increasing projections from MD to rostral, from VLa and VLpv to caudal, and from dorsal VLp (VLpd) to dorsal premotor subareas. Intralaminar nuclei provide widespread projections to all premotor subareas. The degree of overlap between thalamocortical projections varies among different PM and SMA subareas and different sectors of the thalamus. These variations, which correspond to different origin and topography of thalamocortical projections, are discussed in relation to functional organizations at thalamic and cortical levels.
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Medicine
License
License undefined
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Persistent URL
https://folia.unifr.ch/unifr/documents/299808
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