Journal article

Rapid turnover of the “functional” Na⁺–Ca²⁺ exchanger in cardiac myocytes revealed by an antisense oligodeoxynucleotide approach

  • Egger, Marcel Department of Physiology, University of Bern, Switzerland
  • Porzig, Hartmut Department of Pharmacology, University of Bern, Switzerland
  • Niggli, Ernst Department of Physiology, University of Bern, Switzerland
  • Schwaller, Beat Division of Histology, Department of Medicine, University of Fribourg, Switzerland
Show more…
    12.01.2005
Published in:
  • Cell Calcium. - 2005, vol. 37, no. 3, p. 233-243
English Antisense oligodeoxynucleotides (AS-ODNs) were used in combination with transient functional expression of the cardiac Na⁺–Ca²⁺ exchanger (NCX1) to correlate suppression of the Na⁺–Ca²⁺ exchange function with down-regulation of NCX1 protein expression. In a de-novo expression system (Sf9 cells), a decrease in both, NCX1 mRNA and protein after AS-ODN application was paralleled by diminished... Show more…
Faculty
Faculté des sciences et de médecine
Department
Département de Médecine
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299805