Journal article

Developmental origin of wiring specificity in the olfactory system of Drosophila

  • Jefferis, Gregory S. X. E. Department of Biological Sciences, Stanford University, USA
  • Vyas, Raj M. Department of Biological Sciences, Stanford University, USA
  • Berdnik, Daniela Department of Biological Sciences, Stanford University, USA
  • Ramaekers, Ariane Zoology, Department of Biology, University of Fribourg, Switzerland
  • Stocker, Reinhard F. Zoology, Department of Biology, University of Fribourg, Switzerland
  • Tanaka, Nobuaki K. Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
  • Ito, Kei Institute of Molecular and Cellular Biosciences, University of Tokyo, Japan
  • Luo, Liqun Department of Biological Sciences, Stanford University, USA
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    26.11.2003
Published in:
  • Development. - 2004, vol. 131, no. 117-130
English In both insects and mammals, olfactory receptor neurons (ORNs) expressing specific olfactory receptors converge their axons onto specific glomeruli, creating a spatial map in the brain. We have previously shown that second order projection neurons (PNs) in Drosophila are prespecified by lineage and birth order to send their dendrites to one of ~50 glomeruli in the antennal lobe. How can a given class of ORN axons match up with a given class of PN dendrites? Here, we examine the cellular and developmental events that lead to this wiring specificity. We find that, before ORN axon arrival, PN dendrites have already created a prototypic map that resembles the adult glomerular map, by virtue of their selective dendritic localization. Positional cues that create this prototypic dendritic map do not appear to be either from the residual larval olfactory system or from glial processes within the antennal lobe. We propose instead that this prototypic map might originate from both patterning information external to the developing antennal lobe and interactions among PN dendrites.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299736
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