The clock gene Per2 influences the glutamatergic system and modulates alcohol consumption
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Spanagel, Rainer
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Pendyala, Gurudutt
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Abarca, Carolina
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany - Department of Pharmaceutical Chemistry, Experimental Neuropharmacology, Vrije Universiteit Brussel, Brussels, Belgium
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Zghoul, Tarek
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Sanchis-Segura, Carles
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Magnone, Maria Chiara
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland
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Lascorz, Jesús
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Depner, Martin
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Holzberg, David
Max-Planck-Institute for Experimental Endocrinology, Hannover, Germany
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Soyka, Michael
Department of Psychiatry and Psychotherapy, University of Munich, Germany
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Schreiber, Stefan
Institute for Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
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Matsuda, Fumihiko
Centre National de Génotypage, Evry, France
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Lathrop, Mark
Centre National de Génotypage, Evry, France
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Schumann, Gunter
Departments of Psychopharmacology and Psychiatry, Central Institute of Mental Health, Mannheim, Germany
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Albrecht, Urs
Department of Medicine, Division of Biochemistry, University of Fribourg, Switzerland - Max-Planck-Institute for Experimental Endocrinology, Hannover, Germany
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Published in:
- Nature Medicine. - 2004, vol. 11, no. 35-42
English
Period (Per) genes are involved in regulation of the circadian clock and are thought to modulate several brain functions. We demonstrate that Per2Brdm1 mutant mice, which have a deletion in the PAS domain of the Per2 protein, show alterations in the glutamatergic system. Lowered expression of the glutamate transporter Eaat1 is observed in these animals, leading to reduced uptake of glutamate... Show more…
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Faculty
- Faculté des sciences et de médecine
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Department
- Département de Biologie
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Language
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Classification
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Medicine
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License
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License undefined
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Identifiers
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Persistent URL
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https://folia.unifr.ch/unifr/documents/299673