Journal article

Phosphoinositide 3-kinase γ mediates Jun kinase activation via its lipid-kinase activity

  • Pietrucha, Regina Institute for Molecular Cell Biology, University Jena, Germany
  • Rubio, Ignacio Institute for Molecular Cell Biology, University Jena, Germany
  • Wymann, Matthias P. Biochemistry Unit, Medicine Department, University of Fribourg, Switzerland
  • Wetzker, Reinhard Institute for Molecular Cell Biology, University Jena, Germany
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    12.08.2004
Published in:
  • Advances in Enzyme Regulation. - 2004, vol. 44, no. 1, p. 299-308
English Phosphoinositide 3-kinases (PI3K) are bifunctional enzymes expressing lipid- and protein-kinase activities. PI3K lipid kinase is involved in the control of cell motility, survival and other cellular reactions. Recent data point to specific signaling functions of PI3K protein-kinase activities. The PI3K species g has been shown to stimulate major signaling paths to the protein kinases Erk, JNK and PKB, in COS-7 cells. The present work was aimed to decipher the signaling reactions involved in the control of JNK activity by PI3Kg. Using functionally defined mutants we demonstrate an essential role of PI3Kg lipid-kinase activity for JNK stimulation. Together with recent findings these data evidence differential effects of PI3Kg protein- and lipidkinase activities on Erk, JNK and PKB signaling pathways.
Faculty
Faculté des sciences et de médecine
Department
Département de Biologie
Language
  • English
Classification
Biology
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299629
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