Stereospecific Synthesis of Carbanucleotides Designed for Antisense Methodology
- Zhu, Xue-Feng Department of Chemistry of the University of Fribourg, Switzerland
- Nydegger, Freddy Department of Chemistry of the University of Fribourg, Switzerland
- Gossauer, Albert Department of Chemistry of the University of Fribourg, Switzerland
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23.09.2004
Published in:
- Helvetica Chimica Acta. - 2004, vol. 87, no. 9, p. 2245-2265
English
A short stereospecific synthesis of the carbocyclic 2'-deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8,9,10-trinorborn-5-en-2-one (1) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides.
- Faculty
- Faculté des sciences et de médecine
- Department
- Département de Chimie
- Language
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- English
- Classification
- Chemistry
- License
- License undefined
- Identifiers
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- RERO DOC 4817
- DOI 10.1002/hlca.200490202
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299578
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