Journal article

Stereospecific Synthesis of Carbanucleotides Designed for Antisense Methodology

  • Zhu, Xue-Feng Department of Chemistry of the University of Fribourg, Switzerland
  • Nydegger, Freddy Department of Chemistry of the University of Fribourg, Switzerland
  • Gossauer, Albert Department of Chemistry of the University of Fribourg, Switzerland
    23.09.2004
Published in:
  • Helvetica Chimica Acta. - 2004, vol. 87, no. 2245-2265
English A short stereospecific synthesis of the carbocyclic 2'-deoxynucleoside analogues 36 and 37 (Schemes 2 and 5) and 45 and 46 (Schemes 2 and 6) starting from optically active 8,9,10-trinorborn-5-en-2-one (1) is described. As two functional groups capable to react with each other are present in the same molecule of the synthetic carbanucleosides, the latter can form polymers similar to oligonucleotides. Show more…
Faculty
Faculté des sciences
Department
Chimie
Language
  • English
Classification
Chemistry
License
License undefined
Identifiers
Persistent URL
https://folia.unifr.ch/unifr/documents/299578