Bcl-2 family members: intracellular targeting, membrane-insertion, and changes in subcellular localization
- Schinzel, Anna Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany - Biochemistry Unit, Department of Medicine, Fribourg University, Switzerland
- Kaufmann, Thomas Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany - Biochemistry Unit, Department of Medicine, Fribourg University, Switzerland
- Borner, Christoph Institute for Molecular Medicine and Cell Research, Albert-Ludwigs-University Freiburg, Freiburg, Germany
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25.05.2004
Published in:
- Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. - 2004, vol. 1644, no. 2, p. 95-105
Bcl-2 family
subcellular localization
tail-anchoring
membrane insertion
posttranslational modification
translocation
English
The members of the Bcl-2 family of proteins are crucial regulators of apoptosis. In order to determine cell fate, these proteins must be targeted to distinct intracellular membranes, including the mitochondrial outer membrane (MOM), the membrane of the endoplasmic reticulum (ER) and its associated nuclear envelope. The targeting sequences and mechanisms that mediate the specificity of these... Show more…
- Faculty
- Faculté des sciences et de médecine
- Department
- Médecine
- Language
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- English
- Classification
- Biology
- License
- License undefined
- Identifiers
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- RERO DOC 4354
- DOI 10.1016/j.bbamcr.2003.09.006
- Persistent URL
- https://folia.unifr.ch/unifr/documents/299543