Journal article
Nifedipine for high altitude pulmonary oedema.
- Oelz O Department of Medicine, University Hospital Zürich, Switzerland.
- Maggiorini M
- Ritter M
- Waber U
- Jenni R
- Vock P
- Bärtsch P
- 1989-11-25
Published in:
- Lancet (London, England). - 1989
Acute Disease
Administration, Sublingual
Adult
Altitude Sickness
Delayed-Action Preparations
Echocardiography
Emergencies
Humans
Hypoxia
Male
Middle Aged
Nifedipine
Prospective Studies
Pulmonary Edema
Severity of Illness Index
Time Factors
English
In a laboratory at 4559 m six subjects with high altitude pulmonary oedema (HAPO) characterised by clinical signs, severe hypoxaemia, widened alveolar-arterial oxygen gradient, pulmonary hypertension, and alveolar oedema on chest radiography were treated with nifedipine. Despite continued exercise at the same altitude this treatment, without supplementary oxygen, resulted in clinical improvement, better oxygenation, reduction of alveolar arterial oxygen gradient and pulmonary artery pressure, and progressive clearing of alveolar oedema. Nifedipine offers a potential emergency treatment for HAPO when descent or evacuation is impossible and oxygen is not available. The findings also suggest that hypoxic pulmonary hypertension is essential in the pathogenesis of HAPO.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1016/s0140-6736(89)91851-5
- PMID 2573760
- Persistent URL
- https://folia.unifr.ch/global/documents/99267
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