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Influence of surface chemistry and topography of particles on their immersion into the lung's surface-lining layer.

  • 2003-01-28
Published in:
  • Journal of applied physiology (Bethesda, Md. : 1985). - 2003
Administration, Inhalation
Aerosols
Animals
Chemical Phenomena
Chemistry, Physical
Cricetinae
Lung
Male
Mesocricetus
Microscopy, Confocal
Microscopy, Electron, Scanning
Microspheres
Particle Size
Polytetrafluoroethylene
Pulmonary Alveoli
Respiratory Mucosa
Spores, Fungal
Surface Properties
Surface Tension
Tissue Fixation
English Inhaled and deposited spherical particles, 1-6 micrometer in diameter and of differing surface chemistry and topography, were studied in hamster intrapulmonary conducting airways and alveoli by electron microscopy. Polystyrene and Teflon particles, as well as puffball spores, were found submersed in the aqueous lining layer and adjacent to epithelial cells. The extent of particle immersion promoted by a surfactant film was assessed in a "floating-drop-surface balance" by light microscopy. Teflon and polystyrene spheres were immersed into the subphase by 50-60% at film surface tensions of 25 and 30 mJ/m(2), respectively, and totally submersed at 15 and 25 mJ/m(2), respectively. Puffball spores were immersed by approximately 50% at 22 mJ/m(2) and totally submersed at film surface tensions of
Language
  • English
Open access status
green
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Persistent URL
https://folia.unifr.ch/global/documents/9725
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