PAX-6 in development and evolution.
- Callaerts P Department of Cell Biology, Biozentrum, University of Basel, Switzerland.
- Halder G
- Gehring WJ
- 1997-01-01
Published in:
- Annual review of neuroscience. - 1997
Animals
Biological Evolution
DNA-Binding Proteins
Eye Proteins
Homeodomain Proteins
PAX6 Transcription Factor
Paired Box Transcription Factors
Repressor Proteins
Transcription Factors
English
Pax-6 is a member of the Pax gene class and encodes a protein containing a paired domain and a homeodomain. The molecular characterization of Pax-6 genes from species of different animal phyla and the analysis of Pax-6 function in the developing eyes and central nervous system of vertebrates, Drosophila melanogaster, and Caenorhabditis elegans suggest that Pax-6 homologues share conserved functions. In this review, we present recent data on the structural and functional characterization of Pax-6 homologues from species of different animal phyla. We discuss the implications of these findings for our understanding of the development and evolution of eyes and nervous systems.
- Language
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- English
- Open access status
- green
- Identifiers
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- DOI 10.1146/annurev.neuro.20.1.483
- PMID 9056723
- Persistent URL
- https://folia.unifr.ch/global/documents/94098
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