Journal article
Real-time method for motion-compensated MR thermometry and MRgHIFU treatment in abdominal organs.
- Celicanin Z Department of Radiology, Division of Radiological Physics, University of Basel Hospital, Basel, Switzerland; MRC Department, MPI for Biological Cybernetics, Tübingen, Germany.
- Auboiroux V
- Bieri O
- Petrusca L
- Santini F
- Viallon M
- Scheffler K
- Salomir R
- 2013-11-19
Published in:
- Magnetic resonance in medicine. - 2014
MRgHIFU
dynamic HIFU-beam steering
mobile organ
motion correction
temperature mapping
Abdomen
Animals
Artifacts
Body Temperature
Computer Systems
High-Energy Shock Waves
High-Intensity Focused Ultrasound Ablation
Image Enhancement
In Vitro Techniques
Magnetic Resonance Imaging
Motion
Reproducibility of Results
Sensitivity and Specificity
Sheep
Surgery, Computer-Assisted
Thermography
Turkey
Viscera
English
PURPOSE
Magnetic resonance-guided high-intensity focused ultrasound is considered to be a promising treatment for localized cancer in abdominal organs such as liver, pancreas, or kidney. Abdominal motion, anatomical arrangement, and required sustained sonication are the main challenges.
METHODS
MR acquisition consisted of thermometry performed with segmented gradient-recalled echo echo-planar imaging, and a segment-based one-dimensional MR navigator parallel to the main axis of motion to track the organ motion. This tracking information was used in real-time for: (i) prospective motion correction of MR thermometry and (ii) HIFU focal point position lock-on target. Ex vivo experiments were performed on a sheep liver and a turkey pectoral muscle using a motion demonstrator, while in vivo experiments were conducted on two sheep liver.
RESULTS
Prospective motion correction of MR thermometry yielded good signal-to-noise ratio (range, 25 to 35) and low geometric distortion due to the use of segmented EPI. HIFU focal point lock-on target yielded isotropic in-plane thermal build-up. The feasibility of in vivo intercostal liver treatment was demonstrated in sheep.
CONCLUSION
The presented method demonstrated in moving phantoms and breathing sheep accurate motion-compensated MR thermometry and precise HIFU focal point lock-on target using only real-time pencil-beam navigator tracking information, making it applicable without any pretreatment data acquisition or organ motion modeling.
Magnetic resonance-guided high-intensity focused ultrasound is considered to be a promising treatment for localized cancer in abdominal organs such as liver, pancreas, or kidney. Abdominal motion, anatomical arrangement, and required sustained sonication are the main challenges.
METHODS
MR acquisition consisted of thermometry performed with segmented gradient-recalled echo echo-planar imaging, and a segment-based one-dimensional MR navigator parallel to the main axis of motion to track the organ motion. This tracking information was used in real-time for: (i) prospective motion correction of MR thermometry and (ii) HIFU focal point position lock-on target. Ex vivo experiments were performed on a sheep liver and a turkey pectoral muscle using a motion demonstrator, while in vivo experiments were conducted on two sheep liver.
RESULTS
Prospective motion correction of MR thermometry yielded good signal-to-noise ratio (range, 25 to 35) and low geometric distortion due to the use of segmented EPI. HIFU focal point lock-on target yielded isotropic in-plane thermal build-up. The feasibility of in vivo intercostal liver treatment was demonstrated in sheep.
CONCLUSION
The presented method demonstrated in moving phantoms and breathing sheep accurate motion-compensated MR thermometry and precise HIFU focal point lock-on target using only real-time pencil-beam navigator tracking information, making it applicable without any pretreatment data acquisition or organ motion modeling.
- Language
-
- English
- Open access status
- closed
- Identifiers
-
- DOI 10.1002/mrm.25017
- PMID 24243500
- Persistent URL
- https://folia.unifr.ch/global/documents/94061
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