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Model systems for regeneration: Hydra.

  • Vogg MC Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland.
  • Galliot B Department of Genetics and Evolution, Institute of Genetics and Genomics in Geneva (iGE3), Faculty of Sciences, University of Geneva, 30 Quai Ernest Ansermet, CH-1211 Geneva 4, Switzerland brigitte.galliot@unige.ch.
  • Tsiairis CD Friedrich Miescher Institute for Biomedical Research, Maulbeerstrasse 66, CH-4058 Basel, Switzerland.
  • 2019-11-03
Published in:
  • Development (Cambridge, England). - 2019
Genetic manipulations
Hydra model system
Organizer centre
Organoid
Reaggregation
Regeneration
Animals
Gene Editing
Gene Expression Regulation, Developmental
Gene Silencing
Homeostasis
Hydra
Models, Biological
Organoids
Phylogeny
Regeneration
Signal Transduction
Stem Cells
Transgenes
Wnt Proteins
beta Catenin
English The freshwater polyp Hydra provides a potent model system for investigating the conditions that promote wound healing, reactivation of a developmental process and, ultimately, regeneration of an amputated body part. Hydra polyps can also be dissociated to the single cell level and can regenerate a complete body axis from aggregates, behaving as natural organoids. In recent years, the ability to exploit Hydra has been expanded with the advent of new live-imaging approaches, genetic manipulations that include stable transgenesis, gene silencing and genome editing, and the accumulation of high-throughput omics data. In this Primer, we provide an overview of Hydra as a model system for studying regeneration, highlighting recent results that question the classical self-enhancement and long-range inhibition model supposed to drive Hydra regeneration. We underscore the need for integrative explanations incorporating biochemical as well as mechanical signalling.
Language
  • English
Open access status
bronze
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/92713
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