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A new Precursor for the Radiosynthesis of 6-O-(2-[18F]Fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) by Nucleophilic Radiofluorination
Journal article

A new Precursor for the Radiosynthesis of 6-O-(2-[18F]Fluoroethyl)-6-O-desmethyl-diprenorphine ([18F]FE-DPN) by Nucleophilic Radiofluorination

  • Marton, János ABX Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien GmbH, Heinrich-Glaeser-Strasse 10- 14, D-01454 Radeberg, Germany
  • Cumming, Paul Institute of Nuclear Medicine, University of Bern, Inselspital, Freiburgstraße 18, 3010 Bern, Switzerland
  • Bauer, Beate ABX Advanced Biochemical Compounds Biomedizinische Forschungsreagenzien GmbH, Heinrich-Glaeser-Strasse 10- 14, D-01454 Radeberg, Germany
  • Henriksen, Gjermund Institute of Basic Medical Sciences, University of Oslo, P. O. Box 1105, Blindern, N-0317 Oslo, Norway
Published in:
  • Letters in Organic Chemistry. - Bentham Science Publishers Ltd.. - 2020, vol. 17
Organic Chemistry
Biochemistry
English
:
We present the preparation of the new precursor 6-O-(2-tosyloxyethoxy)-6-O-desmethyl-3-O-trityl-diprenorphine
(TE-TDDPN) for a one-pot, two step nucleophilic radiosynthesis of 6-O-(2-[
18F]fluoroethyl-6-O-desmethyl-diprenorphine
([18F]FE-DPN). The route to the precursor consists of a five-step synthesis starting from diprenorphine. We also provide alternative synthesis routes for the cold reference standard and the complete 1H- and 13C-NMR assignment of the prepared derivatives.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/90192
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