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Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.
Journal article

Construction of multifunctional modules for drug discovery: synthesis of novel thia/oxa-azaspiro[3.4]octanes.

  • Li DB Laboratorium für Organische Chemie, ETH Zürich , CH-8093 Zürich, Switzerland, and Discovery Research, Chemistry Technologies & Innovation, F. Hoffmann-La Roche AG , CH-4070 Basel, Switzerland.
  • Rogers-Evans M
  • Carreira EM
  • 2013-09-03
Published in:
  • Organic letters. - 2013
Animals
Aza Compounds
Drug Discovery
Molecular Structure
Octanes
Oxytocin
Spiro Compounds
Stereoisomerism
English New classes of thia/oxa-azaspiro[3.4]octanes are synthesized through the implementation of robust and step-economic routes. The targeted spirocycles have been designed to act as novel, multifunctional, and structurally diverse modules for drug discovery. Furthermore, enantioselective approaches to the spirocycles are reported.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/89238
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