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Comparable survival between HIV+ and HIV− non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation
Journal article

Comparable survival between HIV+ and HIV− non-Hodgkin and Hodgkin lymphoma patients undergoing autologous peripheral blood stem cell transplantation

  • Díez-Martín, José L. Hematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain;
  • Balsalobre, Pascual Hematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain;
  • Re, Alessandro Hematology Department, Spedali Civili, Brescia, Italy;
  • Michieli, Mariagrazia High Dose Chemotherapy and Cellular Therapies Unit, Centro di Riferimento Oncologico, Aviano, Italy;
  • Ribera, José M. Clinical Hematology, Institut Catalá d′Oncologia-Hospital Universitario German Trias i Pujol, Badalona, Spain;
  • Canals, Carmen Biostatistics, European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona, Spain;
  • Conde, Eulogio Hematology Department, Hospital Universitario Marqués de Valdecilla, Universidad de Cantabria, Santander, Spain;
  • Rosselet, Anne Hematology Department, Centre Hospitalier Universitaire Vaudois, Lausane, Switzerland;
  • Gabriel, Ian Hematology Department, Hammersmith Hospital, London, United Kingdom;
  • Varela, Rosario Hematology Department, Complejo Hospitalario Universitario de A Coruña, A Coruña, Spain;
  • Allione, Bernardino Hematology Department, Ospedale Santo Antonio e Biagio, Alessandria, Italy;
  • Cwynarski, Kate Hematology Department, Royal Free Hospital, London, United Kingdom;
  • Genet, Philippe Hematology Department, Hopital Victor Dupouy, Argenteuil, France;
  • Espigado, Ildefonso Hematology Department, Hospital Universitario Virgen del Rocio, Sevilla, Spain;
  • Biron, Pierre Hematology Department, Centre Leon Berard, Lyon, France;
  • Schmitz, Norbert Hematology Department, Asklepios Klinik St. Georg, Hamburg, Germany;
  • Hunter, Anne E. Hematology Department, Leicester Royal Infirmary, Leicester, United Kingdom;
  • Ferrant, Augustin Hematology Department, Cliniques Universitaires St Luc, Brussels, Belgium;
  • Guillerm, Gaelle Hematology Department, Hopital Augustin-Morvan, Brest, France;
  • Hentrich, Mark Hematology Department, Klinikum Harlaching, Munich, Germany;
  • Jurado, Manuel Hematology Department, Hospital Universitario Virgen de las Nieves, Granada, Spain;
  • Fernández, Pascual Hematology Department, Hospital General Alicante, Alicante, Spain;
  • Serrano, David Hematology Department, Hospital General Universitario Gregorio Marañon, Madrid, Spain; and
  • Rossi, Giuseppe Hematology Department, Spedali Civili, Brescia, Italy;
  • Sureda, Anna European Group for Blood and Marrow Transplantation Lymphoma Working Party, Barcelona, Spain
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Published in:
  • Blood. - American Society of Hematology. - 2009, vol. 113, no. 23, p. 6011-6014
Immunology
Cell Biology
Biochemistry
Hematology
English AbstractAutologous stem cell transplantation (ASCT) has been successfully used in HIV-related lymphoma (HIV-Ly) patients on highly active antiretroviral therapy. We report the first comparative analysis between HIV-Ly and a matched cohort of HIV− lymphoma patients. This retrospective European Group for Blood and Marrow Transplantation study included 53 patients (66% non-Hodgkin and 34% Hodgkin lymphoma) within each cohort. Both groups were comparable except for the higher proportion of males, mixed-cellularity Hodgkin lymphoma and patients receiving granulocyte colony-stimulating factor before engraftment and a smaller proportion receiving total body irradiation-based conditioning within the HIV-Ly cohort. Incidence of relapse, overall survival, and progression-free survival were similar in both cohorts. A higher nonrelapse mortality within the first year after ASCT was observed in the HIV-Ly group (8% vs 2%), predominantly because of early bacterial infections, although this was not statistically significant and did not influence survival. Thus, within the highly active antiretroviral therapy era, HIV patients should be considered for ASCT according to the same criteria adopted for HIV− lymphoma patients.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/86133
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