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Urinary 8-isoprostane as a biomarker for oxidative stress. A systematic review and meta-analysis.
Journal article

Urinary 8-isoprostane as a biomarker for oxidative stress. A systematic review and meta-analysis.

  • Graille M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland. Electronic address: MelanieGraille@hotmail.com.
  • Wild P Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland; Institut national de recherche et de sécurité (INRS), Vandoeuvre-lès-Nancy, France. Electronic address: Pascal.Wild@inrs.fr.
  • Sauvain JJ Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland. Electronic address: jean-jacques.sauvain@unisante.ch.
  • Hemmendinger M Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland. Electronic address: maud.hemmendinger@unisante.ch.
  • Guseva Canu I Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland. Electronic address: irina.guseva-canu@unisante.ch.
  • Hopf NB Center for Primary Care and Public Health (Unisanté), University of Lausanne, Route de la Corniche 2, 1066 Epalinges-Lausanne, Switzerland; Swiss Center for Applied Human Toxicology (SCAHT), Missionsstrasse 64, 4055 Basel, Switzerland. Electronic address: Nancy.Hopf@unisante.ch.
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  • 2020-04-23
Published in:
  • Toxicology letters. - 2020
8-isoprostane
F2-isoprostane
Meta-analysis
Oxidative stress
Systematic review
Adult
Biomarkers
Dinoprost
Environmental Exposure
Humans
Oxidative Stress
Smoking
Xenobiotics
English Oxidative stress is defined as an imbalance between the production and elimination of reactive oxygen species (ROS) are associated with various inflammation-related human disease. ROS can oxidize lipids, which subsequently undergo fragmentation to produce F2-isoprostanes (F2-IsoPs). Eight-isoprostane is one of the most extensively studied F2-IsoPs and the most commonly used biomarker for the assessment of oxidative stress in human studies. This urinary biomarker is quantified using either chemical or immunological techniques. A "physiological" range for 8-isoprostanes is needed to use this biomarker as a measure of excess oxidative stress originating from occupational exposures. However, ranges reported in the literature are inconsistent. We designed a standardized protocol of a systematic review and meta-analysis to assess baseline values for 8-isoprostane concentrations in urine of healthy adults and identify determinants of their inter- and intra-individual variability. We searched PubMed from journal inception and up to April 2019, and screened articles for studies containing F2-IsoPs concentrations in urine for healthy adult participants. We grouped studies in three biomarker groups: "8-isoprostane", "Isoprostanes" "15- F2t-Isoprostane". We computed geometric mean (GM) and geometric standard deviation (GSD) as the basis for the meta-analysis. Of the initial 1849 articles retrieved, 63 studies were included and 107 subgroups within these study populations were identified. We stratified the subgroups analyzed with the chemical methods by body mass index (BMI) reported. We provide pooled GM values for urinary 8-isoprostane concentrations in healthy adults, separately for chemical and immunological analysis in this review. The interquartile range (IQR) in subgroups with a mean BMI below 25 measured using chemical methods was 0.18 to 0.40 μg/g creatinine. We show that there is a significant positive association between BMI and urinary 8-isoprostane concentrations. We recommend adjusting urinary 8-isoprostane concentrations in spot urine with creatinine, quantifying 8-isoprostane with chemical analytical methods, and reporting results as median and quartiles. This will help in comparing results across studies.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/83081
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