Journal article
Anterior trunk muscle shows mix of axial and appendicular developmental patterns.
- Sagarin KA Department of Biology, Wesleyan University, Middletown, Connecticut.
- Redgrave AC Department of Biology, Wesleyan University, Middletown, Connecticut.
- Mosimann C Institute of Molecular Life Sciences, University of Zürich, Zürich, Switzerland.
- Burke AC Department of Biology, Wesleyan University, Middletown, Connecticut.
- Devoto SH Department of Biology, Wesleyan University, Middletown, Connecticut.
- 2019-08-07
Published in:
- Developmental dynamics : an official publication of the American Association of Anatomists. - 2019
lateral plate mesoderm
migratory muscle precursors
pectoral fin
posterior hypaxial muscle
sternohyoid
Animals
Cell Differentiation
Cell Movement
Gene Expression Regulation, Developmental
Mesoderm
Muscle, Skeletal
Somites
Zebrafish
English
BACKGROUND
Skeletal muscle in the trunk derives from the somites, paired segments of paraxial mesoderm. Whereas axial musculature develops within the somite, appendicular muscle develops following migration of muscle precursors into lateral plate mesoderm. The development of muscles bridging axial and appendicular systems appears mixed.
RESULTS
We examine development of three migratory muscle precursor-derived muscles in zebrafish: the sternohyoideus (SH), pectoral fin (PF), and posterior hypaxial (PHM) muscles. We show there is an anterior to posterior gradient to the developmental gene expression and maturation of these three muscles. SH muscle precursors exhibit a long delay between migration and differentiation, PF muscle precursors exhibit a moderate delay in differentiation, and PHM muscle precursors show virtually no delay between migration and differentiation. Using lineage tracing, we show that lateral plate contribution to the PHM muscle is minor, unlike its known extensive contribution to the PF muscle and absence in the ventral extension of axial musculature.
CONCLUSIONS
We propose that PHM development is intermediate between a migratory muscle mode and an axial muscle mode of development, wherein the PHM differentiates after a very short migration of its precursors and becomes more anterior primarily by elongation of differentiated muscle fibers.
Skeletal muscle in the trunk derives from the somites, paired segments of paraxial mesoderm. Whereas axial musculature develops within the somite, appendicular muscle develops following migration of muscle precursors into lateral plate mesoderm. The development of muscles bridging axial and appendicular systems appears mixed.
RESULTS
We examine development of three migratory muscle precursor-derived muscles in zebrafish: the sternohyoideus (SH), pectoral fin (PF), and posterior hypaxial (PHM) muscles. We show there is an anterior to posterior gradient to the developmental gene expression and maturation of these three muscles. SH muscle precursors exhibit a long delay between migration and differentiation, PF muscle precursors exhibit a moderate delay in differentiation, and PHM muscle precursors show virtually no delay between migration and differentiation. Using lineage tracing, we show that lateral plate contribution to the PHM muscle is minor, unlike its known extensive contribution to the PF muscle and absence in the ventral extension of axial musculature.
CONCLUSIONS
We propose that PHM development is intermediate between a migratory muscle mode and an axial muscle mode of development, wherein the PHM differentiates after a very short migration of its precursors and becomes more anterior primarily by elongation of differentiated muscle fibers.
- Language
-
- English
- Open access status
- green
- Identifiers
-
- DOI 10.1002/dvdy.95
- PMID 31386244
- Persistent URL
- https://folia.unifr.ch/global/documents/82564
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