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Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction.
Journal article

Activated cytotoxic T cells and NK cells in severe sepsis and septic shock and their role in multiple organ dysfunction.

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  • 2005-07-05
Published in:
  • Clinical immunology (Orlando, Fla.). - 2005
Adult
Aged
Antithrombin III
Apoptosis
Cytokines
Fibrinolysin
Granzymes
Humans
Interleukin-12
Interleukin-12 Subunit p40
Interleukin-6
Killer Cells, Natural
Lymphocyte Activation
Middle Aged
Multiple Organ Failure
Nucleosomes
Peptide Hydrolases
Plasminogen Activator Inhibitor 1
Protein Subunits
Sepsis
Serine Endopeptidases
Shock, Septic
Statistics, Nonparametric
T-Lymphocytes, Cytotoxic
alpha-2-Antiplasmin
fas Receptor
English To evaluate the role of activated cytotoxic cells in patients with severe sepsis (n = 32) or septic shock (n = 8), direct (granzymes A and B) as well as indirect markers (cytokines) for cytotoxic cell activation were measured. Elevated IL-12p40 levels had been detected in 58% of the sepsis patients, whereas only a few had detectable TNF-alpha, IFN-gamma, or IL-12p70 levels. Granzymes A and B levels were elevated in 42.5% and 22.5%, respectively. IL-12p40 inversely correlated with disease severity. Inflammatory parameters (IL-6) and coagulation markers were significantly lower and higher, respectively, in patients with elevated IL-12p40 and granzyme B levels, as compared to those with normal levels. Elevation of granzyme A directly correlated with the increase of apoptotic markers. Activated cytotoxic cells reflected by elevated granzymes A and/or B were found in 50% of our sepsis patients. This group showed a higher mortality and a worse organ function.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/79463
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