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Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment.
Journal article

Cancer Metastasis: A Reappraisal of Its Underlying Mechanisms and Their Relevance to Treatment.

  • Riggi N Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1005 Lausanne, Switzerland; email: Ivan.Stamenkovic@chuv.ch.
  • Aguet M Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1005 Lausanne, Switzerland; email: Ivan.Stamenkovic@chuv.ch.
  • Stamenkovic I Experimental Pathology Service, Centre Hospitalier Universitaire Vaudois, University of Lausanne, CH-1005 Lausanne, Switzerland; email: Ivan.Stamenkovic@chuv.ch.
  • 2017-10-26
Published in:
  • Annual review of pathology. - 2018
CTC
colonization
dormancy
mechanisms
metastasis
stroma
Humans
Neoplasm Invasiveness
Neoplasm Metastasis
Neoplasms
Neoplastic Stem Cells
English Metastases are responsible for the vast majority of cancer-related deaths, but, despite intense efforts to understand their underlying mechanisms with the goal of uncovering effective therapeutic targets, treatment of metastatic cancer has progressed minimally. In this review, we examine the biological programs currently proposed to be key drivers of metastasis. On the basis of evidence from a growing body of research, we discuss to what extent the cellular and molecular mechanisms that are suggested to underlie cancer cell dissemination are specific to the metastatic process, as opposed to representing natural primary tumor progression. Our review highlights the contrast between the abundance of insight gained into the events that constitute the metastatic cascade and the paucity of therapeutic options.
Language
  • English
Open access status
closed
Identifiers
Persistent URL
https://folia.unifr.ch/global/documents/7792
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