Journal article
Impact of early life adversities on human brain functioning: A coordinate-based meta-analysis.
- Kraaijenvanger EJ Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
- Pollok TM Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
- Monninger M Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
- Kaiser A Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
- Brandeis D Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany; Department of Child and Adolescent Psychiatry and Psychotherapy, Psychiatric Hospital, University of Zurich, Zurich, Switzerland; Center for Integrative Human Physiology, University of Zurich, Zurich, Switzerland; Neuroscience Center Zurich, University of Zurich and ETH Zurich, Zurich, Switzerland.
- Banaschewski T Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany.
- Holz NE Department of Child and Adolescent Psychiatry and Psychotherapy, Central Institute of Mental Health, Medical Faculty Mannheim/Heidelberg University, Mannheim, Germany. Electronic address: nathalie.holz@zi-mannheim.de.
- 2020-03-15
Published in:
- Neuroscience and biobehavioral reviews. - 2020
Childhood adversity
Early life stress
Emotion processing
Functional neuroimaging
Latent vulnerability
Memory processing
Prenatal exposure
English
The detrimental impact of early life adversities (ELAs; entailing pre- and postnatal experiences) on the developing brain has been well established. By inducing neural alterations underlying critical human socio-cognitive functions, ELAs may embed latent vulnerability to psychopathologies. However, single neuroimaging studies report conflicting results. Therefore, this coordinate-based meta-analysis aims to identify convergent functional alterations following ELAs. Electronic databases were searched for relevant articles (2001 to June 2019), retrieving 68 eligible studies containing 3685 unique participants. The activation likelihood estimation algorithm was used for analyses according to best-practice guidelines. Whereas pooled analyses did not yield any findings, further homogenizing the experiments revealed significant functional alterations in the left superior frontal gyrus in healthy subjects, left centromedial amygdala during emotion processing, left precuneus during memory processing and left centromedial amygdala and putamen when analyzing the impact of postnatal experiences. These results support the current consensus in the field of environmental imaging: ELAs might exert their effects through systematically altering critical neurocognitive systems and enhance one's vulnerability to future mental health problems.
- Language
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- English
- Open access status
- closed
- Identifiers
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- DOI 10.1016/j.neubiorev.2020.03.008
- PMID 32169412
- Persistent URL
- https://folia.unifr.ch/global/documents/77879
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