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Cardiorespiratory Fitness Mediates Cognitive Performance in Chronic Heart Failure Patients and Heart Transplant Recipients.

  • Besnier F Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Bérubé B Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Gagnon C Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Olmand M Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Ribeiro PAB Research Centre, University of Montreal Hospital Research Centre, Montreal, QC H2X 0A9, Canada.
  • Nigam A Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Juneau M Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Blondeau L Montreal Health Innovations Coordinating Center, Montreal Heart Institute, Montreal, QC H1T 1C8, Canada.
  • White M Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Gremeaux V Sport Medicine Unit, Division of Physical Medicine and Rehabilitation, Swiss Olympic Medical Center, Lausanne University Hospital, 1011 Lausanne, Switzerland.
  • Bherer L Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
  • Gayda M Preventive Medicine and Physical Activity Centre and Research Center, Montreal Heart Institute, Montreal, QC H1T 1N6, Canada.
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  • 2020-11-24
Published in:
  • International journal of environmental research and public health. - 2020
cardiorespiratory fitness
cognition
heart failure
heart transplant
English We compared cognitive profiles in chronic heart failure patients (HF), heart transplant recipients (HT) and healthy controls (HC) and examined the relationship between cardiorespiratory fitness (V˙O2peak), peak cardiac output (COpeak) and cognitive performance. Stable HT patients (n = 11), HF patients (n = 11) and HC (n = 13) (61.5 ± 8.5 years) were recruited. Four cognitive composite scores targeting different cognitive functions were computed from neuropsychological tests: working memory, processing speed, executive functions and verbal memory. Processing speed and executive function scores were higher, which indicates lower performances in HF and HT compared to HC (p < 0.05). V˙O2peak and first ventilatory threshold (VT1) were lower in HF and HT vs. HC (p < 0.01). COpeak was lower in HF vs. HT and HC (p < 0.01). Processing speed, executive function and verbal memory performances were correlated with V˙O2peak, VT1 and peak cardiac hemodynamics (p < 0.05). Mediation analyses showed that V˙O2peak and VT1 mediated the relationship between group and processing speed and executive function performances in HF and HT. COpeak fully mediated executive function and processing speed performances in HF only. V˙O2peak and COpeak were related to cognitive performance in the entire sample. In addition, V˙O2peak and VT1 fully mediated the relationship between group and executive function and processing speed performances.
Language
  • English
Open access status
gold
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Persistent URL
https://folia.unifr.ch/global/documents/77242
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