Journal article

A high-stringency blueprint of the human proteome.

  • Adhikari S Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Nice EC Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Deutsch EW Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Lane L Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
  • Omenn GS Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, 48109-2218, USA.
  • Pennington SR UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
  • Paik YK Yonsei Proteome Research Center, 50 Yonsei-ro, Sudaemoon-ku, Seoul, 120-749, South Korea.
  • Overall CM Faculty of Dentistry, University of British Columbia, Vancouver, BC, Canada.
  • Corrales FJ Functional Proteomics Laboratory, Centro Nacional de Biotecnología-CSIC, Proteored-ISCIII, 28049, Madrid, Spain.
  • Cristea IM Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
  • Van Eyk JE Cedars Sinai Medical Center, Advanced Clinical Biosystems Research Institute, The Smidt Heart Institute, Los Angeles, CA, 90048, USA.
  • Uhlén M Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Lindskog C Rudbeck Laboratory, Department of Immunology, Genetics and Pathology, Uppsala University, 75185, Uppsala, Sweden.
  • Chan DW Department of Pathology and Oncology, Johns Hopkins University School of Medicine, Baltimore, MD, 21224, USA.
  • Bairoch A Faculty of Medicine, SIB-Swiss Institute of Bioinformatics and Department of Microbiology and Molecular Medicine, University of Geneva, CMU, Michel-Servet 1, 1211, Geneva, Switzerland.
  • Waddington JC UCD Conway Institute of Biomolecular and Biomedical Research, School of Medicine, University College Dublin, Dublin, Ireland.
  • Justice JL Department of Molecular Biology, Princeton University, Princeton, NJ, 08544, USA.
  • LaBaer J Biodesign Institute, Arizona State University, Tempe, AZ, USA.
  • Rodriguez H Office of Cancer Clinical Proteomics Research, National Cancer Institute, NIH, Bethesda, MD, 20892, USA.
  • He F State Key Laboratory of Proteomics, Beijing Proteome Research Center, National Center for Protein Sciences (Beijing), Beijing Institute of Lifeomics, Beijing, 102206, China.
  • Kostrzewa M Bruker Daltonik GmbH, Microbiology and Diagnostics, Fahrenheitstrasse, 428359, Bremen, Germany.
  • Ping P Cardiac Proteomics and Signaling Laboratory, Department of Physiology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Gundry RL CardiOmics Program, Center for Heart and Vascular Research, Division of Cardiovascular Medicine and Department of Cellular and Integrative Physiology, University of Nebraska Medical Center, Omaha, NE, 68198, USA.
  • Stewart P Department of Chemical Pathology, Royal Prince Alfred Hospital, Camperdown, NSW, Australia.
  • Srivastava S Indian Institute of Technology Bombay, Powai, Mumbai, 400076, India.
  • Srivastava S Cancer Biomarkers Research Branch, National Cancer Institute, National Institutes of Health, 9609 Medical Center Drive, Suite 5E136, Rockville, MD, 20852, USA.
  • Nogueira FCS Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
  • Domont GB Proteomics Unit and Laboratory of Proteomics, Institute of Chemistry, Federal University of Rio de Janeiro, Av Athos da Silveria Ramos, 149, 21941-909, Rio de Janeiro, RJ, Brazil.
  • Vandenbrouck Y University of Grenoble Alpes, Inserm, CEA, IRIG-BGE, U1038, 38000, Grenoble, France.
  • Lam MPY Departments of Medicine-Cardiology and Biochemistry and Molecular Genetics, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Wennersten S Division of Cardiology, Department of Medicine, University of Colorado, Anschutz Medical Campus, Aurora, CO, USA.
  • Vizcaino JA European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, CB10 1SD, UK.
  • Wilkins M School of Biotechnology and Biomolecular Sciences, University of New South Wales, Sydney, NSW, Australia.
  • Schwenk JM Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Lundberg E Science for Life Laboratory, School of Engineering Sciences in Chemistry, Biotechnology and Health, KTH Royal Institute of Technology, 17121, Solna, Sweden.
  • Bandeira N Department of Computer Science and Engineering, University of California, San Diego, 9500 Gilman Drive, Mail Code 0404, La Jolla, CA, 92093-0404, USA.
  • Marko-Varga G Department of Biomedical Engineering, Lund University, Lund, Sweden.
  • Weintraub ST Department of Biochemistry and Structural Biology, University of Texas Health Science Center San Antonio, UT Health, 7703 Floyd Curl Drive, San Antonio, TX, 78229-3900, USA.
  • Pineau C University of Rennes, Inserm, EHESP, IREST, UMR_S 1085, F-35042, Rennes, France.
  • Kusebauch U Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Moritz RL Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Ahn SB Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia.
  • Palmblad M Leiden University Medical Center, Leiden, 2333, The Netherlands.
  • Snyder MP Department of Genetics, Stanford School of Medicine, Stanford, CA, 94305, USA.
  • Aebersold R Institute for Systems Biology, 401 Terry Avenue North, Seattle, WA, 98109, USA.
  • Baker MS Faculty of Medicine, Health and Human Sciences, Department of Biomedical Sciences, Macquarie University, North Ryde, NSW, 2109, Australia. mark.baker@mq.edu.au.
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  • 2020-10-17
Published in:
  • Nature communications. - 2020
English The Human Proteome Organization (HUPO) launched the Human Proteome Project (HPP) in 2010, creating an international framework for global collaboration, data sharing, quality assurance and enhancing accurate annotation of the genome-encoded proteome. During the subsequent decade, the HPP established collaborations, developed guidelines and metrics, and undertook reanalysis of previously deposited community data, continuously increasing the coverage of the human proteome. On the occasion of the HPP's tenth anniversary, we here report a 90.4% complete high-stringency human proteome blueprint. This knowledge is essential for discerning molecular processes in health and disease, as we demonstrate by highlighting potential roles the human proteome plays in our understanding, diagnosis and treatment of cancers, cardiovascular and infectious diseases.
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  • English
Open access status
gold
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https://folia.unifr.ch/global/documents/76861
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